The FDA Endocrinologic and Metabolic Drugs Advisory Committe turned down Arena Pharmaceutical and its partner Eisais propose for the weight-loss drug lorcaserin, based on a 9 to 5 vote against it. Arena shares fell nearly 40 percent in after-hours trading Thursday to $2.28.
The expert panel was not convinced that the current data could adequately demonstrate the potential benefits of lorcaserin outweighing the potential risks when used long-term in a large population of overweight and obese individuals.
The panelists raised concerns similar to that released by FDA staff earlier this week, mainly the results from Arenas Phase III clinical study did not meet mean efficacy criterion. The BLOOM trial indicated that patients on lorcaserin lost an average of 5.8% of body weight compared with 2.2% in the placebo arm. The expert panel also noted that studies of lorcaserin on rodent model showed breast tumours among those dosed at seven times higher than the proposed clinical dose for humans, but acknowledged that no such increase was seen in the 7,000 patients treated with the drug.
The committe called for more studies to be conducted in people with diabetes, high blood pressure and other health problems, therefore the trial result could reflect patients better if it was approved.
I just couldnt get over that we didnt have a broader population that was representative of people most likely to get this (drug), said Dr. Lamont Weide, an advisory panel member and chief of diabetes and endocrinology at the University of Missouri in Kansas City.
Arena was not totally downbeat after the news; Arena and Eisai believe that lorcaserin has a positive benefit-risk profile, said Arenas president and CEO, Jack Lief, in a statement. Eisai will sell lorcaserin in the US if the drug wins FDA approval. Arena will work closely with the FDA going forward, Lief said. The company has been studying lorcaserin in overweight and obese diabetics and said it expects results later this year.
The FDA will make its verdict by October 22, and usually FDA would follow panel recommendations.
Arena, Vivus and Orexigen are three companies struggling to win the first approval of a new weight-loss drug since Roches Xenical in 1999. Vivus Qnexa failed to gain the support from the EMDAC with a voted 10-6 against it; Orexigens Contrave (sustained-release naltrexone/bupropion) is scheduled to face the panels judgement later this year.
Between attending a baseball game at Coors Field, Colorado Rockies fans will want to take in the sights and sounds of Downtown Denver. They definitely want to book a room at one of the downtown Denver hotels. It is quite easy to find a downtown Denver CO hotel but visitors should research prior to booking. The best bet is to find a downtown Denver hotel that will keep you close to the areas top attractions.
The Marriott Denver City Center is situated in close proximity to Coors Field as well as the dining and shopping districts. This Denver City Center hotel offers its guests panoramic views of the Rocky Mountains and the city skyline.
Some of the top attractions near Coors Field:
1.Six Flags Elitch Gardens- This amusement park offers more than 50 rides, entertainment, dining opportunities and a water park with 11 rides.
2. The Pepsi Center- It is located in the LoDo district of downtown, just north of the University of Colorado-Denver. The Center is home to the NBAs Denver Nuggets and the NHLs Colorado Avalanche. It also hosts concerts and trade shows.
3. The Downtown Aquarium- The Aquarium features over 300 species of underwater life in fourteen different habitats. Visitors can enjoy simulated tide pools and a touch exhibit that allows a more interactive experience with the underwater world. It also has a restaurant, which gives a fantastic view of a fantastic 150,000-gallon aquarium.
4. Childrens Museum- In this museum, there are separate sections for different ages. The toddlers and under area is isolated from the rest of the museum. Theres a Denver fire engine as a big play area. Upstairs is for bigger kids, where there are painting sections, a basketball court, a big wooden train room, and more.
When somebody goes into a nursing home or hospital to get medical care, they are supposed to be confident that they will be protected and well paid attention of. While most health care professionals have the most interests of their patients at spirit all of the time, here is always the chance that somebody can make a mistake. If you suspect that you are the victim of medical misconduct in hospitals, there are steps they should take to get the compensation they are entitled to.
The first things that someone must do it, that they suspect malpractice at medical sector is get a copy of their medical records to check for accuracy. For instance, a medical record might say that a person was in a nonviolent snooze when they were actually in a coma. Missing or mistaken information in medical report is a very big marker that the doctor understands something has gone erroneous.
The next pace that should be taken if someone suspects medical misconduct is assembling with a malpractice lawyer and talking about the options. The most significant thing they must to know is whether you have a case or not at all. A DC Medical Malpractice Lawyer will be able to provide precious information about a patient’s possibility of winning their case and the top way to go about proceedings.
Once a person establishes relations with a medical malpractice attorney, they will have to make some important decisions. The most necessary thing to make a decision is if they will effort to have the same opinion on a settlement with the physician or if they will follow the case in court. To make the settlement faster and simpler is not possible always. An experienced medical malpractice lawyer will be able to offer valuable recommendation to the extent that the best route of action.
Many populaces do not know what to do if they suspect any types of medical malpractice in nursing home or in hospitals, and it can be a very frightening experience. The most significant thing is to take action quickly and establish an affiliation with an attorney that they can trust. No one should vacillate to take action if they believe that they are the fatality of medical malpractice.
Any way whenever you are looking for an attorney in your state or city, visit lawyer directory online. And check various lawyers profile to choose the best attorney.
This sport involves the integration of a lot of abilities. There is the need to perfect the abilities of the players to enable them to soar to better heights. A one person cannot enjoy this game. A person has to take a position on one side while a different person on the other hand to facilitate this task. The ability of a person to train depends on the partner or the existence of a coach. A tennis ball machine permits a single person to enjoy the game. The equipment permits the fans of the game to practice at any time. The decision regarding which abilities to work on may depend on the players. Moreover, the selection on the time of the day to perform the sport depends on the player. People using this device are highly advantaged as in comparison to those individuals who need partners before practicing. These benefits generally stimulate persons from numerous countries to obtain the machine.
A lot of people may would like to train, however, time may not permit them to do so. This case is very well known when persons who need to train have a very tight routine. Fixing the time for training a set routine has shown to be technical. Players who have not acquired their own device may be compelled to move around looking for a best partner. A legible partner should help the player to practice on particular aspects of this sport. This may allow the player to fulfill the aspired goals. Some may choose to search for a coach that will give them lessons concerning the factors of the sport. This system ascertains the elimination of such complications. The appliance permits individuals to training at the proper time.
The players can have a particular shot anytime they are using the equipment. Usually, the system of training with a human being outcomes in plenty of return games. The main purpose behind this is that is associated with various situations of trial and error. Getting a experienced partner may be a very complicated task. A knowledgeable partner may have certain weaknesses that may impede them from getting the expectations of the player. The easily available tool is the cheap tennis ball machine. It is possible to program the device to generate balls at a needed velocity. The tool is able of shooting balls at a lower and a higher speed based on the requires of the needs of the players. Particular brands of this machine have oscillation manages that make sure shots are generated constantly.
Cardiology patients who have received surgically implanted coronary artery stents on a possibly medically unnecessary basis have been contacting their local medical malpractice attorney in greater numbers than ever in the first three months of this year.
Individual as well as class action medical malpractice lawsuits against individual physicians, hospitals, and health care corporations have proliferated after a 2010 audit of coronary artery stent insertions revealed that the procedures were considered to be unwarranted in at least 140 patients at one hospital alone.
Medical malpractice falls under the category of personal injury law. Though an attorney who files a case against a health care professional may refer to himself as a “medical malpractice attorney”, he is in fact licensed and recognized as a personal injury attorney.
A coronary artery stent is an extremely small tube made of flexible wire webbing. A stent is surgically inserted into a clogged coronary artery via the groin or arm in order to help keep a diseased coronary artery open. An unclogged coronary artery is better able to deliver oxygen to the heart and may prevent future episodes of chest pain (angina) and heart attacks. The general standard of care for the procedure known as stenting is indicated when the patient has at least 70% of blockage in a coronary artery. Intravascular ultrasounds with injections of dye are used to determine the extent of the blockage, also known as calcification, in a coronary artery.
Records from the medical malpractice attorneys representing multiple clients state that the standard of minimum 70% blockage has been ignored repeatedly, with the stenting procedures performed on patients with as little as 50% documentation of coronary artery blockage. One lawsuit even accuses the defendants of battery as a result of the patient having undergone unnecessary stent surgery. The patient is claiming extreme emotional distress. The lawsuits contend that both ethical standards and the patients trust were clearly violated, and that informed consent for the procedures was not properly obtained. It is not yet clear what damages the plaintiffs are seeking.
A review of stenting procedures performed in 2009 is currently underway.
R. Klettke is a freelance writer. He writes about personal injury and medical malpractice law and other matters of jurisprudence.
Note: This article is not intended to provide legal advice upon which you should rely in making any decisions regarding the instituting or prosecuting of a legal claim. Laws and rules relating to the bringing of a claim vary widely from state to state. You should always contact a personal injury attorney to obtain information as to the rules and the laws pertaining to any claim you might have.
This is physical therapy that is focused on the “whole” body not just on your injury or condition. Your physical therapist should listen to the history of your problem, before performing tests and measures that will thoroughly assess your condition. You may be tested for muscle strength, joint motion, sensory and neurological conditions, coordination and balance tests, and your movement may be observed.
Working closely with you and your doctor, the physical therapist will design for you a complete physical therapy plan that includes therapeutic exercise. Your physical therapy treatment is based on the initial evaluation findings along with ongoing reassessment and evaluation. Treatment may consist of a variety of hands-on joint and soft tissue treatment techniques, exercise techniques and pain reducing modalities.
Physical Therapy Treatments are designed to help you:
Increase motion and strength
And most importantly, restore function
Patients are typically involved in an active exercise program, and are educated in ways to speed recovery and prevent recurrence of the problem. Your physical therapy program will follow specific protocols or individualized treatment plans with the aim of the physical therapy being the return of your strength, function and mobility.
Therapeutic Exercise From the physical therapy testing, to the specific therapeutic exercise program, you will recognize that physical therapy is a science. Your therapeutic exercise program is your plan for recovery. It is important to have access to the very best equipment.
You will be trained and monitored on the use of all physical therapy equipment to ensure that you are getting the full benefit from your therapeutic exercise program. Therapeutic exercise will help restore your strength, movement, balance, and coordination. You will learn how to deal with your current problem, and how to prevent it in from reoccurring in the future.
The physical therapists at Physical Medicine of NY & CT have combined experience of over 50 years. If you suffer from acute or chronic pain, or are recovering from surgery or an accident, find out more about Physical Therapy that is focused on you from Physical Medicine of NY & CT.
Malta Doctor – A Chirpy Old General Medical Practitioner (Licensed Physician and Surgeon), who is currently based in the Sovereign Maltese Territories of Southern Mediterranean Europe.
From his Compact Seaside (Tourists) Clinic in the Northern Part of St Pauls Bay , he Humorously Sizzles Highly Contentious Healthcare Issues , primarily concerning the Sunny Little Islands of Malta, Gozo and Comino ; Sumptuously Marinated and Garnished (of course) with Shocking Administrative Intrigues, Awesome Political Machinations and Frightful Machiavellic Happenings at Health Ministry HQ (Palazzo Castellania).
Therapeutic Clinical Sarcasm is Delightfully Served Up in Highly Empowering Doses ; most especially Every Blessed Sunday.
Kevin MD – Americas Most Influential Medical Blog.
Dr Kevin Pho is a Practising, Board-Certified , Internal Medicine Physician , who eagerly runs a Punchy, Prolific Blog , which effortlessly chronicles Americas (often dysfunctional) Health Care System ; through the (Crystal-Clear) Prism of an unbiased Primary Care Provider.
Vampys Weblog – Asias Most Entertaining Medical Blog.
Shocking Rants (and Horrifying Raves) of a Busy Young Medical Officer in Singapore.
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Music is very important for human in all ages, so it is important to learn music since the young age. Learning music will train your concentration, sensitivity and release the stress. There are many advantages in learning music. If you want to learn music, then music lessons in Lone Tree, CO can be a good choice. This music course is available for all ages. The lessons will be divided based on age such as Music for Little Mozart, this course is aimed for children in the age of 3 and 4 years old.
The children will learn how to play piano; they will learn how to listen. In this piano class, the children are introduced with the concept of music such as singing, movement and listening to music rhythm patterns. Then there is Junior Music Course for the children in the age of 4 and 5 years old. The children will learn how to write a note, reading a note of music, singing and others. This activity will be really fun for children. By learning music, the children also will understand their subject at school better, because the music will train their concentration and release the stress.
For the advanced level is YAMAHA Keyboard Encounters for the children in the age of 10 and above. In this class, the children or adult will use their creativity in playing piano. The children will express their feeling through music, so if you as parent are interested to send your children this The Piano Play House. You may call 303.909.8365 for further information or arranging the schedule. The location of this piano class is at The Piano Playhouse 8100 S. Quebec St. Unit B201 Centennial 80112. You may also find the information related with piano class in the official website of The Piano Playhouse. The children will learn the music in a fun and attractive ways since the young age.
It seems like hundreds of skincare and grooming products are available to men these days and more are being added all the time. But how many of them include high-performance ingredients? How many of them provide effective results? And which ones are really necessary to maintain great-looking skin with a minimum amount of effort?
How to classify your skin type:
The first step to finding the right products for you is deciding what type of skin type you have. Most products target several individual skin types: oily skin, dry skin, sensitive skin, acne-prone skin and combination skin.
Oily skin: Feels slightly greasy or slick to the touch, with larger pores. It is usually more prone to blackheads and whiteheads. Look for products that are ultralight and oil-free, and exfoliating items that will remove oil and dirt.
Dry skin: Often feels tight and itchy and is more prone to irritations. Look for products that contain hydrating ingredients like Aloe, Urea and Allantoin, and pay special attention to moisturizers. Keep in mind that moisture is not the same thing as oil, so you dont need heavy, oily products to achieve good levels of hydration for your skin.
Sensitive skin: Easily irritated by skincare or shaving products or extreme weather conditions. Look for products that do not contain dyes, fragrances or irritants and are specially formulated for sensitive skin.
Normal skin: If havent had any reoccurring skin problems such as shininess, acne or irritated skin, you probably have normal skin. Unless a product states otherwise, most skincare items can be used by men with normal skin.
Combination skin: Most men fall into this category, having dry patches and oily patches on their face at the same time (oily patches often fall in the T-Zone: your forehead and down your nose to your chin). Look for products that gently clean skin without harsh abrasives and moisturizers that are ultralight.
Acne-prone skin: Can partner with oily skin, but is also a factor with people with dry skin. This type tends to break out frequently with pimples, blackheads or whiteheads. Look for products that are noncomedgenic (not pore-clogging) and contain ingredients like benzoyl peroxide.
How to identify effective skincare products for men:
Once youve zeroed in on what type of skin you have, concentrate on finding products that appeal to that type, or products recommended for all skin types. Easier said then done, right? Theres still a sea of products out there. How can you decide which you need and which ones are nothing more than fancy packaging?
A good idea is to start with a very basic skin care routine that involves four steps: Cleaning, Exfoliating, Shaving, and Moisturizing. That means you should look for a gentle liquid cleanser for your face, an exfoliating scrub, a shaving product, an aftershave product and an oil-free moisturizer. If you start with these basic items, you cant really go wrong.
Healthcare facilities in the US are increasing on a steady basis and alongside, the scope for in these hospitals and medical centers is also increasing. To meet the changing needs of the healthcare environment, talented professionals are in high demand in the medical facilities. Healthcare jobs involve supporting and helping out physically challenged people.
Find the Right Job Providers
Skilled and experienced candidates can easily find jobs in medical centers including hospitals, nursing centers, research facilities, rehabilitation clinics and other facilities. To make the job hunt easier, most of the candidates depend on recruiting agencies, where they can find a range of job listings. They help the candidates to find the right job suiting their specific requirements such as location, payment, nature of job and more.
Rehabilitation Personnel in Diverse Specialties
is open for a range of rehabilitation professionals including physical therapists, physical therapist assistants, occupational therapist, occupational therapist assistants, speech language pathologists, pharmacists and nurses. Dedicated specialists can earn the best in the industry with their specific talent and skill in the particular field. Short-term or long-term and part-time or full-time job vacancies exist in numerous hospitals and medical facilities. Depending on the needs of these medical facilities, you can find the job that is most suitable for you.
Benefits Provided with Healthcare Jobs
Healthcare insurance, professional liability insurance, short-term disability insurance, additional state license, cancer insurance, 401k benefits, continuing state license and other privileges are available for healthcare professionals. Internationally trained candidates are given assistance in clearing all the visa formalities, documentation and orientation upon arrival.
Above all, if you are a well-trained and well-qualified person, you can easily advance your career in this field. You can create and submit an online resume to find the appropriate job suiting your requirement within no time.
TheraKare, a well-known in the USA, offers fast and efficient placement solutions for medical professionals. Our are offered to hospitals and medical centers.